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BIBTEX RIS

Parkin Plays a Role in Sporadic Parkinson's Disease

2013; Karger Publishers; Volume: 13; Issue: 2-3 Linguagem: Inglês

10.1159/000354307

ISSN

1660-2862

Autores

Ted M. Dawson, Valina L. Dawson,

Tópico(s)

Alzheimer's disease research and treatments

Resumo

<b><i>Background:</i></b> Parkinson's disease (PD) is a chronic progressive neurologic disorder, which affects approximately one million men and women in the US alone. PD represents a heterogeneous disorder with common clinical manifestations and, for the most part, common neuropathological findings. <b><i>Objective:</i></b> This short article reviews the role of the ubiquitin E3 ligase in sporadic PD. <b><i>Methods:</i></b> The role of parkin in sporadic PD was reviewed by querying PubMed. <b><i>Results:</i></b> Parkin is inactivated in sporadic PD via S-nitrosylation, oxidative and dopaminergic stress, and phosphorylation by the stress-activated kinase c-Abl, leading to the accumulation of AIMP2 and PARIS (ZNF746). <b><i>Conclusion:</i></b> Strategies aimed at maintaining parkin in a catalytically active state or interfering with the toxicity of AIMP2 and PARIS (ZNF746) offer new therapeutic opportunities.

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