347 PREVALENCE OF INFLAMMATION AND PROSTATE CARCINOMA IN ASIAN AND CAUCASIAN MEN: AN AUTOPSY STUDY
2013; Lippincott Williams & Wilkins; Volume: 189; Issue: 4S Linguagem: Inglês
10.1016/j.juro.2013.02.1733
ISSN1527-3792
AutoresAlexandre R. Zlotta, Shinichi Egawa, Dmitry Pushkar, Alexander Govorov, Takahiro Kimura, Masahito Kido, Hiroyuki Takahashi, Cynthia Kuk, М. В. Ковылина, Najla Aldaoud, Neil Fleshner, Antonio Finelli, Laurence Klotz, Jenna Sykes, Gina Lockwood, Theodorus van der Kwast,
Tópico(s)Cardiovascular Disease and Adiposity
ResumoYou have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History (II)1 Apr 2013347 PREVALENCE OF INFLAMMATION AND PROSTATE CARCINOMA IN ASIAN AND CAUCASIAN MEN: AN AUTOPSY STUDY Alexandre R Zlotta, Shin Egawa, Dmitry Pushkar, Alexander Govorov, Takahiro Kimura, Masahito Kido, Hiroyuki Takahashi, Cynthia Kuk, Marta Kovylina, Najla Aldaoud, Neil E Fleshner, Antonio Finelli, Laurence Klotz, Jenna Sykes, Gina Lockwood, and Theodorus H van der Kwast Alexandre R ZlottaAlexandre R Zlotta Toronto, Canada , Shin EgawaShin Egawa Tokyo, Japan , Dmitry PushkarDmitry Pushkar Moscow, Russian Federation , Alexander GovorovAlexander Govorov Moscow, Russian Federation , Takahiro KimuraTakahiro Kimura Tokyo, Japan , Masahito KidoMasahito Kido Tokyo, Japan , Hiroyuki TakahashiHiroyuki Takahashi Tokyo, Japan , Cynthia KukCynthia Kuk Toronto, Canada , Marta KovylinaMarta Kovylina Moscow, Russian Federation , Najla AldaoudNajla Aldaoud Toronto, Canada , Neil E FleshnerNeil E Fleshner Toronto, Canada , Antonio FinelliAntonio Finelli Toronto, Canada , Laurence KlotzLaurence Klotz Toronto, Canada , Jenna SykesJenna Sykes Toronto, Canada , Gina LockwoodGina Lockwood Toronto, Canada , and Theodorus H van der KwastTheodorus H van der Kwast Toronto, Canada View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.1733AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Chronic inflammation has been known to contribute to several forms of cancer. Recent but controversial data have suggested that prostatic inflammation might also be involved in the pathogenesis of prostate cancer (PCa). In the REDUCE trial, chronic histologic inflammation was found in 78% of men, reflecting its ubiquitous nature whereas acute inflammation was found in 16.5% of the study population. Few studies have analyzed the relationship between inflammation (acute and chronic) and PCa on autopsy specimens and none compared Asian (ASI) to Caucasian (CAU) men. The primary goal of this study was to investigate the prevalence of inflammation among PCa in ASI and CAU men in autopsy specimens. METHODS Prostate glands were prospectively obtained during autopsy from men who died from other causes than PCa in Moscow (Russia)-(CAU) and Tokyo (Japan)-(ASI). Prostates were removed en-block within 24 hours of death, immediately injected with buffered formalin (pH 7.3), placed in buffered formalin for two to three days at room temperature and analyzed in toto. Identification of PCa, its Gleason score (GS) and, acute inflammation (grade 0-3) and chronic inflammation (grade 0-3) was assessed by an experienced uro-pathologist. We compared and correlated across the ASI and CAU populations the presence or absence of acute or chronic inflammation, their degree of severity and the presence of PCa and GS. We used the Cochran Armitage test for trend, Spearman correlation, the chi-square test and Wilcoxon tests for statistical analyses. RESULTS 320 prostates were collected, 220 from CAU and 100 from ASI men. Mean age was 62.5 and 68.5 years in CAU and ASI men, respectively (p<0.001). Chronic inflammation was found in 72.0 and 75.9% of ASI and CAU men, respectively (no significant difference). Chronic inflammation was strongly associated with older age and acute inflammation (all p<0.001). There was no evidence of an association between acute inflammation and PCa or ethnicity. We observed a significant association between GS7 and chronic inflammation (p=0.015). CONCLUSIONS Chronic inflammation is associated with PCa on autopsy both in Asian and Caucasian men and interestingly, with cancers presenting aggressive features (GS≥7). No evidence of a causal relation can be proven at this stage but this topic clearly deserves scrutiny and additional research. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e140 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Alexandre R Zlotta Toronto, Canada More articles by this author Shin Egawa Tokyo, Japan More articles by this author Dmitry Pushkar Moscow, Russian Federation More articles by this author Alexander Govorov Moscow, Russian Federation More articles by this author Takahiro Kimura Tokyo, Japan More articles by this author Masahito Kido Tokyo, Japan More articles by this author Hiroyuki Takahashi Tokyo, Japan More articles by this author Cynthia Kuk Toronto, Canada More articles by this author Marta Kovylina Moscow, Russian Federation More articles by this author Najla Aldaoud Toronto, Canada More articles by this author Neil E Fleshner Toronto, Canada More articles by this author Antonio Finelli Toronto, Canada More articles by this author Laurence Klotz Toronto, Canada More articles by this author Jenna Sykes Toronto, Canada More articles by this author Gina Lockwood Toronto, Canada More articles by this author Theodorus H van der Kwast Toronto, Canada More articles by this author Expand All Advertisement Advertisement Loading ...
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