Advanced Glycation End Products in Children With Type 1 Diabetes: Family Matters?
2011; American Diabetes Association; Volume: 35; Issue: 1 Linguagem: Inglês
10.2337/dc11-1398
ISSN1935-5548
AutoresPascal Barat, B. Cammas, A. Lacoste, Jérôme Harambat, V. Vautier, Fabienne Nacka, Jean-Benoît Corcuff,
Tópico(s)Diabetes and associated disorders
ResumoAdvanced glycation end product (AGE) burden can be indirectly quantified in vivo by measuring skin autofluorescence (SAF) (1). It has been recently published by Felipe et al. (2) that SAF is correlated with glycated hemoglobin (GHb) but not with mean blood glucose (MBG) in type 1 diabetic children. This suggests that factors besides MBG exposure may be influential in skin AGE generation. In the current study, we have compared SAF in type 1 diabetic children and their nondiabetic sibling. We included 52 type 1 diabetic children, 55% boys, aged 12 (6) years [median (interquartile range: 75th percentile − 25th percentile)], and 28 nondiabetic siblings, 46% boys, aged 11 (6) years. Among diabetic children, the duration of diabetes was 71 (45) …
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