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Protease M/neurosin mRNA is expressed in mature oligodendrocytes

1999; Elsevier BV; Volume: 71; Issue: 2 Linguagem: Inglês

10.1016/s0169-328x(99)00187-4

1872-6941

Hiroki Yamanaka, Xiao‐Ping He, Kazumasa Matsumoto, Sadao Shiosaka, Shigetaka Yoshida,

Neuroinflammation and Neurodegeneration Mechanisms

No proteases have been identified to be oligodendrocyte-specific though there are phenomena in which proteases may be committed. We have cloned a cDNA for mouse homologue of protease M/neurosin, serine protease, and localized its mRNA in the mouse brain. The cDNA and the deduced amino acid sequences were 66% identical to those of human protease M/neurosin. In situ hybridization histochemistry revealed that the mRNA was localized in the mature oligodendrocytes which expressed proteolipid protein mRNA. Developmentally, protease M/neurosin mRNA was expressed by oligodendrocytes 2 to 7 days after the maturation. Thus, protease M/neurosin may be important to the processes occurring after the maturation of oligodendrocytes such as myelination or turnover of the proteins in the myelin.