CD7 expression distinguishes subsets of CD4+ T cells with distinct functional properties and ability to support replication of HIV-1
2000; Wiley; Volume: 30; Issue: 2 Linguagem: Inglês
10.1002/1521-4141(200002)30
ISSN1521-4141
AutoresDiana L. Wallace, Patricia M. Matear, Derek Davies, Ray Hicks, Christelle Lebossé, Josiah Eyeson, Peter C. L. Beverley, Annapurna Vyakarnam,
Tópico(s)Reproductive System and Pregnancy
ResumoEnrichment of a subset of CD4+CD45R0+CD7– T cells has been observed in HIV-infected individuals. We have investigated the ability of CD7+ and CD7– T cells to support replication of HIV and show that virus replicates preferentially in CD7+ cells. Several possible mechanisms that may underlie such differences in susceptibility to HIV were studied. Our data demonstrate that mitogen stimulation induces poor expression of CD25 and IL-2 in CD7– compared with CD7+ cells. We also show that uninfected CD7– cells are more resistant to mitogen-induced apoptosis than CD7+ cells. Our data support the view that the CD7– subset is inherently resistant to HIV replication and that this is due in part to reduced CD25 expression and IL-2 production.
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