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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Modulation of Sodium Pumps by Steroidal Saponins

2004; De Gruyter; Volume: 59; Issue: 5-6 Linguagem: Inglês

10.1515/znc-2004-5-626

ISSN

1865-7125

Autores

Aloa Machado de Souza, Lucienne S. Lara, José O. Previato, Aníbal Gil Lopes, Celso Caruso‐Neves, Bernadete Pereira da Silva, José Paz Parente,

Tópico(s)

Phytochemical Studies and Bioactivities

Resumo

Costus spicatus, used in Brazilian traditional medicine to expel kidney stones, contains steroidal saponins with different chemical characteristics. In spite of its popular utilization as potent diuretic, no scientific reports correlate this activity with the chemical constituents of the extract. Therefore, two steroidal saponins (3β,22a,25R)-26-(β-ᴅ-glucopyranosyloxy)-2-methoxyfurost-5-en-3-yl O-ᴅ-apio-β-ᴅ-furanosyl-(1→2)-O-[6-deoxy-α-ʟ-mannopyranosyl- (1→4)]-β-ᴅ-glucopyranoside (1) and (3β,22α,25R)-spirostan-3-yl O-ᴅ-apio-β-ᴅ-furanosyl- (1→2)-O-[6-deoxy-α-ʟ-mannopyranosyl-(1→4)]-β-ᴅ-glucopyranoside (la), were isolated from the rhizomes of this plant and their effects on the Na + -ATPase and (Na + +K + )-ATPase activities of the proximal tubule from pig kidney were evaluated. It was observed that 1 and la inhibit specifically the Na + -ATPase activity.

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