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Pyridoxine Absorption from the Small Intestine of the X-Irradiated Rat

1964; Radiation Research Society; Volume: 21; Issue: 2 Linguagem: Inglês

10.2307/3571558

1938-5404

Lawrence E. Detrick, H.C. Upham, R.W. Springsteen, Ruth G. McCandless, Thomas J. Haley,

Biochemical effects in animals

The in situ pyridoxine absorption by the intestines of rats receiving 525 r of total-body irradiation showed two deviations from the normal absorption pattern. A profound decrease in absorption was observed during the first postirradiation week, with the greatest decrease on day three, and a secondary decrease from the tenth to the seventeenth postirradiation day. Electron microscope studies indicate mitochondrial damage from irradiation. The possible mechanisms involved in these effects were discussed. (auth)