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The Serologic Marker CA 19-9 and Pancreatic Cancer

1989; American College of Physicians; Volume: 111; Issue: 2 Linguagem: Inglês

10.7326/0003-4819-111-2-184

1539-3704

David A. Nardone,

Hepatitis B Virus Studies

Letters and Corrections15 July 1989The Serologic Marker CA 19-9 and Pancreatic CancerDavid A. Nardone, MDDavid A. Nardone, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-2-184 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: The serologic marker for pancreatic cancer, CA 19-9, is more useful than presented in the study by Pleskow and colleagues (1). Its value is not shown by comparing CA 19-9 to carcinoembryonic antigen at a cutoff of 70 U/mL (P< 0.0001) but by doing calculations for true-positive rates (sensitivity), false-positive rates (1 — specificity), and for likelihood ratio-positive at different cutoff points: for 10 000 U/ mL: true-positive rate, 0.19; false-positive rate, 0.01; likelihood ratio-positive, 19; for 1000 U/mL: true-positive rate, 0.39; false-positive rate, 0.01; likelihood ratio-positive, 39; for 100 U/mL: true-positive rate, 0.63; false-positive rate, 0.10; likelihood ratio-positive, 6.3; and for 70 U/mL: true-positive rate, 0.70; false-positive rate,...References1. PleskowBergerGyvesAllenMcLeanPodolsky DHJEAD. Evaluation of a serologic marker, CA 19-9, in the diagnosis of pancreatic cancer. Ann Intern Med. 1989;110:704-9. LinkGoogle Scholar2. Measuring the accuracy of clinical data. In: Sox HC Jr., Blatt MA, Higgins MC, Marton KI, eds. Medical Decision Making. Boston: Butterworths; 1988:123-4. Google Scholar3. Centor R. A Visicalc program for estimating the area under a receiver operating characteristic (ROC) curve. Med Decis Making. 1985;5:139-48. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Veterans Administration Medical Center Portland, OR 97225 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiagnosing cancer of the pancreas. 15 July 1989Volume 111, Issue 2Page: 184-185KeywordsCarcinoembryonic antigenPancreatic cancerSpecificity Issue Published: 15 July 1989 PDF downloadLoading ...