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Caspase-1 is active since the early phase of rheumatoid arthritis

2010; BioMed Central; Volume: 8; Issue: S1 Linguagem: Inglês

10.1186/1479-5876-8-s1-p35

1479-5876

Rita Cascão, Joaquim Polido‐Pereira, Helena Canhão, Ana Maria Rodrigues, Márcio Navalho, Helena Raquel, Ana Filipa Mourão, Cristina Maria Mendes Resende, João Eurico Fonseca, Luís Moita,

Toxin Mechanisms and Immunotoxins

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint destruction. We have previously reported an increase in interleukin (IL)-1β levels in the serum of very early RA and in the synovial fluid (SF) of RA patients. Therefore, the molecular mechanisms that regulate IL-1β activation, such as caspase-1, might play a relevant role and have potential as therapeutic targets in RA.