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BIBTEX RIS

Volumetric Evidence of Bilateral Damage in Unilateral Mesial Temporal Lobe Epilepsy

2006; Wiley; Volume: 47; Issue: 8 Linguagem: Inglês

10.1111/j.1528-1167.2006.00605.x

1528-1167

David Araújo, Antônio Carlos dos Santos, Tonicarlo Rodrigues Velasco, Lauro Wichert‐Ana, Vera C. Terra, Veriano Alexandre, Carlos Gilberto Carlotti, João Alberto Assirati, Hélio Rubens Machado, Roger Walz, João Pereira Leite, Américo Ceiki Sakamoto,

Neurological disorders and treatments

Summary: Purpose: We sought to analyze the contralateral volumes of the temporal pole, posterior segment of the temporal lobe, amygdala, hippocampus, and parahippocampal gyrus in patients with temporal lobe epilepsy (TLE) due to histologically proven mesial temporal lobe sclerosis (MTLS), seizure free for ≥4 years of postsurgical follow‐up. Methods: Forty‐six (23 male) TLE patients, operated on between 1996 and 2001, with histopathologic diagnosis of MTLS, and a postsurgical follow‐up of ≥4 years, had their temporal lobe structures manually segmented, measured, and compared with those of 23 normal volunteers, paired as groups for sex, age, and handedness. Results: The mean volumes of the contralateral temporal pole, hippocampus, and parahippocampal gyrus in TLE patients were significantly lower than those in controls. Conclusions: MRI volumetric data show that the damage in TLE due to MTS may be more widespread and bilateral, even in patients with unilateral TLE by clinical and neurophysiological criteria. Our results are relevant to the discussion of epileptogenic mechanisms in TLE.