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Sunflower Seed Oil-Enriched Product Can Inhibit Ehrlich Solid Tumor Growth in Mice

2006; Karger Publishers; Volume: 52; Issue: 2 Linguagem: Inglês

10.1159/000091308

1421-9794

Lucilene A. Silva, Kátia A.F. Nascimento, Márcia Cristina Gonçalves Maciel, Mayara T. Pinheiro, Paulo R.A. Sousa, Susanne C.P. Ferreira, Ana Paula Silva de Azevedo dos Santos, Rosane Nassar Meireles Guerra, Flávia Raquel Fernandes do Nascimento,

Lipid metabolism and biosynthesis

<i>Background:</i> Sunflower seed oil (SSO) effect on solid and ascitic forms of Ehrlich tumor was evaluated. <i>Methods:</i> Solid or ascitic Ehrlich tumor-bearing Swiss mice were treated daily, by subcutaneous route, with 200 µl of SSO. The solid tumor-bearing footpad was measured every 3 days and ascitic tumor-bearing mice had their ascites collected and quantified. At the end of the SSO treatment, the total cell number in lymphoid organs was quantified. <i>Results:</i> Subcutaneous treatment with SSO inhibits the solid tumor growth and increases lymph node cell number in animals with solid tumor, but has no effect on animals with ascitic tumor. <i>Conclusions:</i> SSO can delay the solid tumor growth, possibly due to better absorption of this treatment by draining lymph nodes.