Crosstalk between integrin and receptor tyrosine kinase signaling in breast carcinoma progression
2010; Korean Society for Biochemistry and Molecular Biology; Volume: 43; Issue: 5 Linguagem: Inglês
10.5483/bmbrep.2010.43.5.311
ISSN1976-670X
AutoresYoung-Hwa Soung, John L. Clifford, Jun Chung,
Tópico(s)Cancer Cells and Metastasis
ResumoThis review explored the mechanism of breast carcinoma progression by focusing on integrins and receptor tyrosine kinases (or growth factor receptors). While the primary role of integrins was previously thought to be solely as mediators of adhesive interactions between cells and extracellular matrices, it is now believed that integrins also regulate signaling pathways that control cancer cell growth, survival, and invasion. A large body of evidence suggests that the cooperation between integrin and receptor tyrosine kinase signaling regulates certain signaling functions that are important for cancer progression. Recent developments on the crosstalk between integrins and receptor tyrosine kinases, and its implication in mammary tumor progression, are discussed.
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