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Gluconeogenesis from alanine in endotoxin-treated dogs

1978; Elsevier BV; Volume: 25; Issue: 2 Linguagem: Inglês

10.1016/0022-4804(78)90072-0

1095-8673

Robert E. Kuttner, John J. Spitzer,

Cancer, Hypoxia, and Metabolism

Gluconeogenesis from alanine was studied in fasted, anesthetized, E. coli endotoxin-treated dogs by continous infusion of l-[U-14C]alanine. A marked increase in plasma alanine occurred following endotoxin. Alanine turnover remained unchanged. The fraction of glucose carbon derived from alanine was 9% at 4 hr after endotoxin, a threefold increase over control dog values. Incorporation of carbon-14 label into plasma protein was depressed in experimental animals over 40% at the same time period. The data suggest that, in early endotoxemia, gluconeogenesis from alanine may actually increase.