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Prior knowledge for time domain quantification of in vivo brain or liver 31 P MR spectra

2003; Wiley; Volume: 16; Issue: 3 Linguagem: Inglês

10.1002/nbm.821

1099-1492

Gavin Hamilton, Nayna Patel, Daniel Forton, Joseph V. Hajnal, Simon D. Taylor‐Robinson,

Lanthanide and Transition Metal Complexes

Abstract Prior knowledge is required when quantifying in vivo 31 P magnetic resonance spectra from the brain or liver. The prior knowledge system we have used models both the phosphomonoester and phosphodiester resonances as two peaks of equal linewidth and fixed relative chemical shift. The analysis of the data is carried out in the time domain, which allows the broad component of the spectra to be modelled. This prior knowledge method has been tested for analysis of in vivo 31 P MR spectra from the liver and brain and gives results consistent with other methods that are also used to analyse the spectra, but with reduced variability. This technique may be utilized for studies requiring serial MR spectroscopy examinations, before and after patient treatment. Copyright © 2003 John Wiley & Sons, Ltd.