A Versatile Catalyst System for Suzuki−Miyaura Cross-Coupling Reactions of C(sp 2 )-Tosylates and Mesylates
2009; American Chemical Society; Volume: 11; Issue: 17 Linguagem: Inglês
10.1021/ol9015892
ISSN1523-7060
AutoresBrijesh Bhayana, Brett P. Fors, Stephen L. Buchwald,
Tópico(s)Synthetic Organic Chemistry Methods
ResumoA catalyst system for the Suzuki−Miyaura cross-coupling reactions of aryl and vinyl tosylates and mesylates has been developed. This catalyst displays excellent functional group tolerance and allows the coupling of heteroarylboronic acids with aryl tosylates and mesylates to be performed in high yields. Moreover, reactions employing alkylboronic acids, as well as heteroaryl, vinyl, and allylic pinacol boronate esters, were conducted with high efficiencies.
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