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BIBTEX RIS

Dependence of cellular potential on ionic concentrations. Data supporting a modification of the constant field equation

1983; Elsevier BV; Volume: 43; Issue: 2 Linguagem: Inglês

10.1016/s0006-3495(83)84335-5

ISSN

1542-0086

Autores

Donald C. Chang,

Tópico(s)

Photoreceptor and optogenetics research

Resumo

The resting potential in the squid axon has been measured at various concentrations of Cl, K, Na, and Ca ions.The results of these measurements are compared with the Goldman-Hodgkin-Katz (GHK) equation and a modified constant field equation.This modified equation was derived by including currents carried by divalent ions and the effects of the unstirred layer and the periaxonal space.It is shown that, although the GHK equation can fit the Vvs.[KJO data well, it has difficulty explaining the observed dependence of Von [Na]0 when the axon is bathed in K-free artificial sea water.The use of the modified constant field equation removes this difficulty.

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