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Structure of the activating IL-1 receptor signaling complex

2012; Nature Portfolio; Volume: 19; Issue: 4 Linguagem: Inglês

10.1038/nsmb.2260

1545-9993

Christoph Thomas, J. Fernando Bazán, K. Christopher García,

Inflammasome and immune disorders

Interleukin-1 (IL-1)-family cytokines are mediators of innate and adaptive immunity. They exert proinflammatory effects by binding a primary receptor that recruits a receptor accessory protein to form a signaling-competent heterotrimeric complex. Here we present the crystal structure of IL-1β bound to its primary receptor IL-1RI and its receptor accessory protein IL-1RAcP, providing insight into how IL-1-type cytokines initiate signaling and revealing an evolutionary relationship with the fibroblast growth factor receptor family.