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Metabolic Abnormalities of Lactic Acid in Burkitt-type Lymphoma with Malignant Effusions

1966; American College of Physicians; Volume: 65; Issue: 1 Linguagem: Inglês

10.7326/0003-4819-65-1-101

1539-3704

Jerome B. Block,

Mitochondrial Function and Pathology

Case Studies1 July 1966Metabolic Abnormalities of Lactic Acid in Burkitt-type Lymphoma with Malignant EffusionsJEROME B. BLOCK, M.D., WILLIAM R. BRONSON, M.D., WILLIAM R. BELL, M.D.JEROME B. BLOCK, M.D.Search for more papers by this author, WILLIAM R. BRONSON, M.D.Search for more papers by this author, WILLIAM R. BELL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-1-101 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptElevations of blood lactic acid rarely are observed in patients with cancer uncomplicated by shock or hypoxia. However, Field, Block, and Rall (1) and Field, Block, Levin, and Rall (2) noted an occasional relationship between extensive leukemia and development of clinical lactic acidosis. They suggested that lactic acid produced by leukemic tissue may be the cause of such a metabolic disorder although leukemic cells are paradoxically characterized by low in vitro rates of glycolysis (2-6), in contrast to most malignant neoplasms (7-10).Recently, a patient with "Burkitt's lymphoma" was admitted to the National Cancer Institute. The initial manifestations of the...References1. FIELDBLOCKRALL MJBDP: Lactic acidosis in acute leukemia (abstract). Clin. Res. 11: 193, 1963. Google Scholar2. FIELDBLOCKLEVINRALL MJBRDP: The significance of elevations of blood lactate in patients with neoplastic and other proliferative disorders. Amer. J. Med. 40: 528, 1966. CrossrefGoogle Scholar3. BECKVALENTINE WSWN: Aerobic carbohydrate metabolism of leukocytes in health and leukemia. Cancer Res. 12: 818, 1952. MedlineGoogle Scholar4. MCKINNEYRUNDLES GRRW: Lactate formation and glyoxalase activity in normal and leukemic human leukocytes in vitro. Cancer Res. 16: 67, 1956. 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