A CONVENIENT ONE-POT SYNTHESIS OF 4-HYDROXYCOUMARIN, 4-HYDROXYTHIOCOUMARIN, AND 4-HYDROXYQUINOLIN-2(1 H )-ONE
2001; Taylor & Francis; Volume: 31; Issue: 8 Linguagem: Inglês
10.1081/scc-100104003
ISSN1532-2432
AutoresJae‐Chul Jung, Young‐Jo Jung, Oee‐Sook Park,
Tópico(s)Synthesis and biological activity
ResumoAn improved one-pot synthesis of 4-hydroxycoumarin, 4-hydroxythiocoumarin, and 4-hydroxyquinolin-2(1H)-one from 2-hydroxyacetophenone, 2-mercaptoacetophenone, and 2-aminoacetophenone, respectively, is described. The synthetic strategies involve the acylation and internal ring cyclization. This method is readily amenable to large-scale synthesis of 4-hydroxycoumarin, 4-hydroxythiocoumarin, and 4-hydroxyquinolin-2(1H)-one derivatives in high yields.
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