Tumor markers carcinoembryonic antigen, CA 50, and CA 19-9 and squamous cell carcinoma of the esophagus pretreatment screening
1988; Wiley; Volume: 62; Issue: 11 Linguagem: Inglês
10.1002/1097-0142(19881201)62
ISSN1097-0142
AutoresEva Munck‐Wikland, Richard Kuylenstierna, Britta Wahrén, Johan Lindholm, S. Haglund,
Tópico(s)Lung Cancer Research Studies
ResumoPretreatment serum levels of the tumor markers Carcinoembryonic antigen (CEA), CA 50, and CA 19-9 in 95 patients with squamous cell carcinoma of the esophagus and 32 age-matched controls were compared. Thirty-nine percent of the cancer patients showed elevated (≥5 μg/l) serum CEA levels, 41% had elevated (≥17 U/ml) CA 50 levels, and 13% showed elevated (≥37 U/ml) CA 19-9 levels. The tumor markers showed a considerable degree of complementarity, and combined tumor marker analysis increased the sensitivity to 59%. Raised CEA levels were found significantly more frequently in intrathoracically localized tumors than in cervical cancers. Patients surviving less than 6 months showed a higher rate of elevated CEA assays than those who survived 6 to 18 months. No certain correlation was established between tumor marker elevation and tumor stage or tumor differentiation.
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