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3q−, 3q+ anomaly in malignant proliferations in humans

1983; Elsevier BV; Volume: 9; Issue: 4 Linguagem: Inglês

10.1016/0165-4608(83)90085-7

1873-4456

Cristina Mecucci, Kristina Vermaelen, Guido Tricot, A. Louwagie, Jean‐Louis Michaux, André Bosly, José Thomas, Dario Barbieri, Herman Van den Berghe,

Eosinophilic Disorders and Syndromes

Anomalies of both No. 3 chromosomes, of the t(3q−; 3q+) type can be observed in human malignancy as reported previously. It is our experience that this anomaly is found predominantly in myeloproliferative disorders, as a rather rare event, though occurring more frequently than similar exchanges between other homologous chromosomes. Previous claims about a relationship between this anomaly and thrombocytosis could not be confirmed, but the features found in a few patients indicate that further research should be undertaken to clarify this point.