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Assessment of parent-of-origin effect in familiesunlineally affected with panic disorder-agoraphobia

1999; Elsevier BV; Volume: 33; Issue: 1 Linguagem: Inglês

10.1016/s0022-3956(98)00038-7

1879-1379

Marco Battaglia, Silvana Bertella, Sonia Bajo, Flora Binaghi, Anna Ogliari, Laura Bellodi,

Epigenetics and DNA Methylation

While the mode of transmission of psychiatric disorders remains elusive new paradigms to investigate the genetics of mental illnesses + Kennedy 0884# are sug! gested by the recent _ndings reported by some but not studies of bipolar illness and schizophrenia McMa! hon et al[ 0884^ Petronis + Kennedy 0884# of tri! nucleotide repeat TNR# ampli_cations i[e[ genetic mutations where quantitative changes in phenotype cor! respond to the size of the expansion of one group of simple trinucleotides repeats# the related phenomena of anticipation i[e[ the decrease of age at onset or the increase in severity in successive generations# and parent! of!origin e}ect i[e[ di}erential expression of diseases alleles depending on whether the genetic material has come from the mother or the father#[ Our recent _nding of anticipation of age at onset of _rst panic attack and of panic disorder!agoraphobia PDA# et al 0887# led us to assess the possible presence of a parent!of!origin e}ect in the same set of pedigrees[ This investigation is based on a family study of thirty! eight unilineal multigenerational families with multiple subjects with PDA taken from a study group of 440 consecutive outpatients[ This was an extension of a pre! vious study group with the original recruitment and methods unchanged et al[ 0884^ Battaglia et al[ 0887#[ Direct interviews with 54) of all living _rst! and second!degree relatives n 212# were and 61) of all a}ected relatives were directly interviewed while family histories from multiple informants were obtained for the remaining subjects n 063#[ In addition to the transmission of disease!related tri! nucleotide repeats from a parent to his:her o}spring Paulson + Fischbeck 0885# an observed parent!of! origin e}ect can derive from mitochondrial inheritance Hall et al[ 0889# and genomic imprinting Skuse et al[ 0886#[