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Comparison of the antiplatelet agent potential of the whole molecule, F(ab)2 and fab fragments of humanized anti-GPIIb/IIIa monoclonal antibody in monkeys

1996; Elsevier BV; Volume: 27; Issue: 3 Linguagem: Inglês

10.1016/0306-3623(95)02057-8

1879-0011

Seiji Kaku, Shinya Yano, Tomihisa Kawasaki, Yumiko Sakai, Kenichi Suzuki, Koji Kawamura, Yasuhiko Masuho, Noboru Satoh, Toichi Takenaka, Nicholas F. Landolfi, Man Sung Co,

Heparin-Induced Thrombocytopenia and Thrombosis

1. The potential antiplatelet agent use of the whole molecule, F(ab)2 and Fab fragments of humanized antiglycoprotein (GP) IIb/IIIa monoclonal antibody, hC4G1, were investigated in rhesus monkeys. 2. Fab completely inhibited platelet aggregation 1 hr after an IV bolus administration of 1 mg/kg without a decrease in platelet count or prolongation of bleeding time, and the duration of inhibition was much shorter than that of F(ab)2 3. These results suggest that the Fab fragment of hC4G1 may be a more useful antiplatelet agent in patients with acute thromboembolic diseases than the whole molecule or F(ab)2 fragments.