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Episodic-like memory: New perspectives from a behavioral test in rats

2012; Imperial College Press; Volume: 11; Issue: 01 Linguagem: Inglês

10.1142/s021963521250001x

1757-448X

Victoria I. Weisz, Mariana Ríos, Pablo Argibay,

Neuroendocrine regulation and behavior

Journal of Integrative NeuroscienceVol. 11, No. 01, pp. 1-15 (2012) ArticlesNo AccessEpisodic-like memory: New perspectives from a behavioral test in ratsVictoria I. Weisz, Mariana B. Rios, and Pablo F. ArgibayVictoria I. WeiszUnit of Cognitive Science, Instituto de Ciencias Básicas y Medicina Experimental, Hospital Italiano de Buenos Aires, Potosí 450, C1199ACL, Buenos Aires, Argentina, Mariana B. RiosUnit of Cognitive Science, Instituto de Ciencias Básicas y Medicina Experimental, Hospital Italiano de Buenos Aires, Potosí 450, C1199ACL, Buenos Aires, Argentina, and Pablo F. ArgibayUnit of Cognitive Science, Instituto de Ciencias Básicas y Medicina Experimental, Hospital Italiano de Buenos Aires, Potosí 450, C1199ACL, Buenos Aires, Argentinahttps://doi.org/10.1142/S021963521250001XCited by:1 Next AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail AbstractIn order to have a tool to empirically test the ideas derived from a theoretical model, we extended a protocol for evaluation of episodic-like memory in rats, based on the triad "what, where, context" for definition of memories. As with the computational model, our intention was for the animal being tested to store a specific number of object-place-context configurations as different memories, which would then be retrievable from cues. The aim of this work was to evaluate the influence of the number of configurations to be memorized on the performance of the task. Sixty-five Wistar male rats were evaluated. In accordance with previous work, for two configurations, the recognition index was indicative of recognition of the element mismatching the original memory (mean = 0.28; SEM = 0.12). The recognition index for three configurations was lower (mean = 0.15; SEM = 0.10), evidencing less recall with increasing requirements. The results also showed a trend toward recognition of novelty for the first and the last memory when evaluating three configurations (a "U" shape in the exploratory preference's curve), showing the primacy and recency effects typical of memory both in humans and animals. Nonetheless, the data presented a high inter-subject variability which makes the test non-robust for small groups. 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Crossref, Medline, ISI, Google Scholar FiguresReferencesRelatedDetailsCited By 1Integration of memory, perception and attention in episode processingEva Čadež16 April 2014 | Journal of Integrative Neuroscience, Vol. 13, No. 01 Recommended Vol. 11, No. 01 Metrics History Received 29 March 2011 Accepted 9 September 2011 KeywordsEpisodic-like memoryhippocampusratsPDF download