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Viability effects and recombination differences in a linkage test with pallid and fidget in the house mouse

1961; Springer Nature; Volume: 16; Issue: 4 Linguagem: Inglês

10.1038/hdy.1961.54

1365-2540

Walter F. Bodmer,

Plant Reproductive Biology

THE recessive gene pallid (pa) (Roberts, I 931) causes a dilution of the coat colour, pink eyes and an abnormality of the labyrinth (Lyon, 1953).It has generally been found to reduce viability to some extent.Fidget (fi) is one of the "shaker" group of mutants.It is a recessive which was first described by Gruneberg (iz).Affected animals are generally smaller and weaker than normal mice in the early stages of their development.This results in a marked reduction in both their viability and fertility.The two genes are known to be situated in linkage group V (Roberts and Quisenberry, 1935;Carter and Gruneberg, 1950; Wallace, '95°).The viability effects of pa and fi and the fact that they are linked make them well suited to an analysis of viability effects and interactions in a balanced linkage experiment, using the methods of analysis developed by Bodmer and Parsons (1959a, b) and BodmerThe only linkage test using both pa and fi is due to Carter (i')and is based on intercrosses.This region of chromosome V is, however, one which has been subject to much investigation.Sex differences in recombination have been reported by Fisher and Landauer (1953), Wallace (1957) and Parsons (1958a), and an effect of age on recom-