Produção Nacional
Revisado por pares
Effects of splenic allograft in lipid profile of non-splenectomized rats: the immune and metabolic role of the "double spleen"
2014; Brazilian College of Surgeons; Volume: 41; Issue: 2 Linguagem: Inglês
10.1590/s0100-69912014000200009
ISSN1809-4546
AutoresThiago Barbosa Gonçalves, Vítor Nagai Yamaki, Daniel Haber Feijó, Luís Eduardo Almeida de Souza, Edvaldo Lima Silveira, Marcus Vinícius Henriques Brito, Andy Petroianu,
Tópico(s)Lipid metabolism and disorders
ResumoTo elucidate the role of the spleen and splenic allograft in lipid control and evaluate its effect on the lipid profile of rats.32 male Wistar rats were randomly assigned into four groups: control group (1), total splenectomy group (2), splenectomy and implantation of allograft group (3) and double spleen group (4). Each group was subdivided into two subgroups: A and B, based on the death of the animals after 30 or 120 days of monitoring. The procedures in groups 2, 3 and 4 were made simultaneously, and splenectomized animals, groups 2 and 3 were donors, respectively, for the animals of groups 3 and 4. In group 4 the spleen was preserved and the animals received implants from the spleens of rats from group 3. The regeneration of splenic tissue was evaluated by macroscopic and microscopic analyzes of the grafts and own spleens, as well as with measurements of VLDL, HDL, LDL, total cholesterol and triglycerides.after 120 days, Group 4 showed levels of total cholesterol and LDL lower than the other groups. Group 1 had higher levels of lipids.The technique of double spleen was effective in the control of lipid metabolism, corroborating the function of the spleen as a reserve of lipids.
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