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Chitinase secreted by Leishmania functions in the sandfly vector

1991; Royal Society; Volume: 245; Issue: 1313 Linguagem: Inglês

10.1098/rspb.1991.0097

1471-2954

Yosef Schlein, Raymond L. Jacobson, Joseph Shlomai,

Invertebrate Immune Response Mechanisms

Restricted accessMoreSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Cite this article Schlein Yosef , Jacobson Raymond L. and Shlomai Joseph 1991Chitinase secreted by Leishmania functions in the sandfly vectorProc. R. Soc. Lond. B.245121–126http://doi.org/10.1098/rspb.1991.0097SectionRestricted accessArticleChitinase secreted by Leishmania functions in the sandfly vector Yosef Schlein Google Scholar Find this author on PubMed Search for more papers by this author , Raymond L. Jacobson Google Scholar Find this author on PubMed Search for more papers by this author and Joseph Shlomai Google Scholar Find this author on PubMed Search for more papers by this author Yosef Schlein Google Scholar Find this author on PubMed , Raymond L. Jacobson Google Scholar Find this author on PubMed and Joseph Shlomai Google Scholar Find this author on PubMed Published:22 August 1991https://doi.org/10.1098/rspb.1991.0097AbstractLeishmania major parasites ingested with host blood by the sandfly Phlebotomus papatasi multiply confined within the peritrophic membrane. This mem brane consists of a chitin framework and a protein carbohydrate matrix and it is secreted around the food by the insect midgut. Histological sections of infected flies show lysis of the chitin layer in the anterior region of the peritrophic membrane that permits the essential forward migration of a concentrated mass of parasites. Both the location and the nature of this disintegration are specific to infected flies. At a later stage the parasites concentrate in the cardiac valve region and subsequently this segment of the fore gut loses its cuticular lining. We have found that chitinase and A-acetylglucosaminidase are secreted by cultured L. major promastigotes, but not by sandfly guts. Hence lysis of the chitin layer of the peritrophic membrane could be catalysed by these enzymes of the parasites. Activity of both enzymes was also observed in other trypanosomatids, including L. donovani, L. infantum, L. braziliensis, Leptomonas seymouri, Crithidia fasciculata and Trypanosoma lewisi. FootnotesThis text was harvested from a scanned image of the original document using optical character recognition (OCR) software. As such, it may contain errors. Please contact the Royal Society if you find an error you would like to see corrected. Mathematical notations produced through Infty OCR. 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