Produção Nacional
Revisado por pares
Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review
2014; Dove Medical Press; Linguagem: Inglês
10.2147/ijn.s65616
ISSN1178-2013
AutoresLionel Fernel Gamarra, Larissa Alvarim, Leopoldo Penteado Nucci, Javier Bustamante Mamani, Luciana Cavalheiro Marti, Marina Fontes de Paula Aguiar, Hélio Tedesco‐Silva, Gisele Sampaio Silva, Mariana Penteado Nucci, Elaine Aparecida Del Bel,
Tópico(s)Graphene and Nanomaterials Applications
ResumoAbstract: The increase in clinical trials assessing the efficacy of cell therapy for structural and functional regeneration of the nervous system in diseases related to the aging brain is well known. However, the results are inconclusive as to the best cell type to be used or the best methodology for the homing of these stem cells. This systematic review analyzed published data on SPION (superparamagnetic iron oxide nanoparticle)-labeled stem cells as a therapy for brain diseases, such as ischemic stroke, Parkinson's disease, amyotrophic lateral sclerosis, and dementia. This review highlights the therapeutic role of stem cells in reversing the aging process and the pathophysiology of brain aging, as well as emphasizing nanotechnology as an important tool to monitor stem cell migration in affected regions of the brain. Keywords: iron oxide, dementia, stem cell, stroke, Parkinson's disease, sclerosis disease, brain aging
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