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Measurement of peak inspiratory flow with in-check dial device to simulate low-resistance (Diskus) and high-resistance (Turbohaler) dry powder inhalers in children with asthma

2005; Wiley; Volume: 39; Issue: 5 Linguagem: Inglês

10.1002/ppul.20180

8755-6863

Israel Amirav, Michael T. Newhouse, Yasser Mansour,

Asthma and respiratory diseases

Pediatric PulmonologyVolume 39, Issue 5 p. 447-451 Original Article Measurement of peak inspiratory flow with in-check dial device to simulate low-resistance (Diskus) and high-resistance (Turbohaler) dry powder inhalers in children with asthma Israel Amirav MD, Corresponding Author Israel Amirav MD Department of Pediatrics, Sieff Hospital, Safed, IsraelDepartment of Pediatrics, Sieff Hospital, Safed, Israel 13100.Search for more papers by this authorMichael T. Newhouse MD, MSc, FRCP(C), FACP, FCCP, Michael T. Newhouse MD, MSc, FRCP(C), FACP, FCCP Barnett Medical Aerosol Research Laboratory, St. Joseph Hospital, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorYasser Mansour MD, Yasser Mansour MD Pediatric Pulmonary Unit, Rambam Medical Center, Haifa, IsraelSearch for more papers by this author Israel Amirav MD, Corresponding Author Israel Amirav MD Department of Pediatrics, Sieff Hospital, Safed, IsraelDepartment of Pediatrics, Sieff Hospital, Safed, Israel 13100.Search for more papers by this authorMichael T. Newhouse MD, MSc, FRCP(C), FACP, FCCP, Michael T. Newhouse MD, MSc, FRCP(C), FACP, FCCP Barnett Medical Aerosol Research Laboratory, St. Joseph Hospital, McMaster University, Hamilton, Ontario, CanadaSearch for more papers by this authorYasser Mansour MD, Yasser Mansour MD Pediatric Pulmonary Unit, Rambam Medical Center, Haifa, IsraelSearch for more papers by this author First published: 29 March 2005 https://doi.org/10.1002/ppul.20180Citations: 40AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Drug delivery and lung deposition from a dry powder inhaler (DPI) are dependent on the peak inspiratory flow (PIF) through the DPI. Therefore, when prescribing a DPI, it is important to know whether a child is able to generate sufficient PIF through a particular device. Using a PIF meter (In-Check Dial) that mimics the internal resistance of DPIs, two commonly used devices (high-resistance Turbohaler (TH) and low-resistance Diskus (DK)) determined the PIF generated by asthmatic children through each of them. Two hundred and twenty-three children were studied, of whom 100 (mean age, 9.1 ± 3.0 years; range, 3–15 years) were experienced with the use of a DPI (>1 month of regular DPI use), and 123 (mean, 5.5 ± 1.9 years; range, 3–9 years) were inexperienced (no previous DPI use). All of the experienced patients generated more than 30 l/min through both devices, but a PIF of 60 l/min through the TH was obtained by only 68 (68%) of them. The age above which a minimal PIF of 30 l/min (for DK) or 60 l/min (for TH) could be achieved in new DPI users (inexperienced) was 4 years and 9 years, respectively. Even among experienced patients, many young children may not generate optimal PIFs through high-resistance DPIs. When DPI treatment is considered for young children, some devices may be successfully introduced at a younger age. It may thus be important to measure PIF in children who use a DPI or in whom DPI use is contemplated. This evaluation can be easily undertaken in the clinic with the In-Check Dial device. Pediatr Pulmonol. © 2005 Wiley-Liss, Inc. Citing Literature Volume39, Issue5May 2005Pages 447-451 RelatedInformation