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Cancer‐associated fibroblast and M 2 macrophage markers together predict outcome in colorectal cancer patients

2013; Wiley; Volume: 104; Issue: 4 Linguagem: Inglês

10.1111/cas.12096

1349-7006

Mercedes Herrera, Alberto Herrera, Gemma Domínguez, Javier Silva, Vanesa Garcı́a, José Manuel García, Irene Gómez, Beatriz Soldevilla, Concepción Muñoz, Mariano Provencio, Yolanda Campos‐Martín, Antonio Garcı́a de Herreros, J. Ignacio Casal, Félix Bonilla, Cristina Peña,

Cancer, Hypoxia, and Metabolism

Tumor epithelial cells within a tumor coexist with a complex microenvironment in which a variety of interactions between its various components determine the behavior of the primary tumors. Cancer‐associated fibroblasts ( CAF ) and M 2 macrophages, characterized by high expression of different markers, including α‐ SMA , FSP 1 and FAP , or CD 163 and DCSIGN , respectively, are involved in the malignancy of different tumors. In the present study, expression of the above markers in CAF and M 2 macrophages was analyzed using RT ‐ PCR and immunohistochemistry in the normal mucosa and tumor tissue from a cohort of 289 colorectal cancer patients. Expression of CAF and M 2 markers is associated with the clinical outcome of colorectal cancer patients. Moreover, the combination of CAF and M 2 markers identifies three groups of patients with clear differences in the progression of the disease. This combined variable could be a decisive factor in the survival of advanced‐stage patients. Taken together, these analyses demonstrate the prognostic involvement of interrelationships between DCSIGN , CD 163, α‐ SMA , FSP 1 and FAP markers in the survival of colon cancer patients.