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Aromatic δ-Peptides

2003; American Chemical Society; Volume: 125; Issue: 12 Linguagem: Inglês

10.1021/ja029887k

1943-2984

Hua Jiang, Jean‐Michel Léger, Ivan Huc,

Carbohydrate Chemistry and Synthesis

Oligoamides of 8-amino-2-carboxy-quinoline adopt a very stable helical conformation characterized in solution by 1H NMR and in the solid state by single-crystal X-ray diffraction. The helix comprises only 2.5 units per turn, which represents the highest curvature achieved by aromatic oligoamides until now. Monomers possessing alkoxy substituents in position 4 are easily available from 2-nitroaniline and dimethyl acetylenedicarboxylate.