MicroRNA 125a and its regulation of the p53 tumor suppressor gene
2009; Wiley; Volume: 583; Issue: 22 Linguagem: Inglês
10.1016/j.febslet.2009.10.002
ISSN1873-3468
AutoresYingjie Zhang, Jinsong Gao, Xiaoli Tang, Lynne Tucker, Peter J. Quesenberry, Isidore Rigoutsos, Bharat Ramratnam,
Tópico(s)Cancer-related molecular mechanisms research
ResumoMicroRNA (miRNA) are a class of non‐coding RNA that suppress gene expression by degradation or translational inhibition of target RNA. Several miRNA have been shown to target oncogenes and recently miRNA‐125b was shown to translationally and transcriptionally inhibit the p53 gene. Here, we show that an additional isomer of miRNA‐125 (miRNA‐125a) translationally arrests mRNA of the p53 tumor suppressor gene. The basis of this activity is the high degree of sequence homology between the seed sequence of miR‐125a and the 3′‐UTR of p53. Our findings add miRNA‐125a to the growing list of miRNA with oncogenic targets.
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