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JNK or IKK, AP-1 or NF-κB, which are the targets for MEK kinase 1 action?

1998; National Academy of Sciences; Volume: 95; Issue: 16 Linguagem: Inglês

10.1073/pnas.95.16.9067

1091-6490

Michael Karin, Mireille Delhase,

Genomics, phytochemicals, and oxidative stress

Gene expression variation is shaped by both genetic and environmental effects, yet these two factors are rarely considered together in the context of adaptive evolution. We studied environmental influences on gene regulatory evolution in ...Changes in gene expression are thought to play a major role in adaptive evolution. While it is known that gene expression is highly sensitive to the environment, very few studies have determined the influence of genetic and environmental effects on ...