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Healing potential of Pequi (Caryocar coriaceum Wittm.) fruit pulp oil

2009; Elsevier BV; Volume: 2; Issue: 4 Linguagem: Inglês

10.1016/j.phytol.2009.06.002

1876-7486

Glauberto da Silva Quirino, Gerlânia de Oliveira Leite, Luciana Magalhães Rebêlo Alencar, Adriana da Rocha Tomé, José Galberto Martins da Costa, André Herzog Cardoso, Adriana Rolim Campos,

Essential Oils and Antimicrobial Activity

Caryocar coriaceum Wittm. (Caryocaraceae), popularly known as Pequi, is a common tree frequently used in folk medicine to treat many types of afflictions, such as wound lesions, gastric and inflammatory diseases. The present study was undertaken to evaluate the healing potential of the pulp oil from C. coriaceum (OCC) in rats and mice. OCC was tested by monitoring wound contraction in incised wounds and topical application of OCC accelerated wound contraction in open wounds. The mean values of wound contraction in pulp oil treated rats on day 16 were 6.25 ± 0.51% as against 4.17 ± 0.28% seen in control and the difference was statistically significant (p < 0.01). Gastric lesions induced by ethanol and aspirin were significantly reduced by OCC (200 and 400 mg/kg, p < 0.05). Pretreatment of mice with yohimbine, indomethacin, l-NAME or glibenclamide greatly suppressed the gastroprotective effect of OCC. Thus we provide the first evidence that OCC reduces gastric damage induced by ethanol, at least in part, by mechanisms that involve α2-receptors, endogenous prostaglandins, nitric oxide and K+ATP channels. These results indicate the beneficial effect of C. coriaceum on wound and gastric healing and justify its traditional use for the treatment of wounds and gastric ulcers.