Composite fibrin and collagen scaffold to enhance tissue regeneration and angiogenesis
2007; Elsevier BV; Volume: 7; Linguagem: Inglês
10.1016/j.cap.2006.11.026
ISSN1878-1675
AutoresYoung Il Yang, Dong Lim Seol, H.I. Kim, M.H. Cho, S.J. Lee,
Tópico(s)Wound Healing and Treatments
ResumoThe goal of this study is to determine optimal composition of fibrin matrix and to develop a smart composite fibrin and collagen scaffold for tissue regeneration and angiogenesis. Human dermal fibroblasts (HDFs) showed more rapid F-actin assembly and cell migration in a three-dimensional fibrin matrix consisting of a physiologic range of fibrinogen concentrations. Microvascular and cellular densities of the composite fibrin and collagen scaffold implanted into nude mice were significantly higher than for a porous collagen matrix without fibrin (p < 0.01). Histomorphometrically, stromal cell ingrowths, CD31-positive microvasculatures, and deposition of ECM matrix were more evenly distributed in the composite scaffold. The results demonstrate that fibrin admixed with porous collagen sponges can be used as a smart template for tissue regeneration.
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