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The renal clearance of inulin, creatinine, trimethoprim and sulphadoxine in horses

1979; Wiley; Volume: 2; Issue: 4 Linguagem: Inglês

10.1111/j.1365-2885.1979.tb00399.x

1365-2885

HANS GELSÅ,

Drug Transport and Resistance Mechanisms

The clearance of inulin and creatinine were almost identical in horses, indicating that creatinine clearance can be used for estimation of the glomerular filtration rate in horses. Trimethoprim (TMP) is excreted in urine by glomerular filtration, active tubular secretion and back‐diffusion. The clearance of TMP is highly influenced by urine pH, but also by the plasma concentration of the drug and by the degree of diuresis. The results indicate self‐depression of the active tubular secretion of TMP at plasma concentrations above 1–2 μg/ml. The renal excretion of sulphadoxine in horses involves glomerular filtration and a pronounced back‐diffusion. The clearance of sulphadoxine is dependent on urine pH and increases with increasing pH. The clearance of N 4 ‐acetyl sulphadoxine was higher than the clearance of the parent compound. The renal excretion of N 4 ‐acetyl sulphadoxine was shown to involve glomerular filtration, active tubular secretion and back‐diffusion.