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Association of distinct clinical subsets with myositis‐specific autoantibodies towards anti‐155/140‐kDa polypeptides, anti‐140‐kDa polypeptides, and anti‐aminoacyl tRNA synthetases in Japanese patients with dermatomyositis: a single‐centre, cross‐sectional study

2009; Taylor & Francis; Volume: 38; Issue: 4 Linguagem: Inglês

10.1080/03009740802687455

1502-7732

Keita Fujikawa, Atsushi Kawakami, K. Kaji, Manabu Fujimoto, Shin‐ya Kawashiri, Naoki Iwamoto, Toshiyuki Aramaki, Kunihiro Ichinose, Mami Tamai, Makoto Kamachi, Hideki Nakamura, Hiroaki Ida, Tomoki Origuchi, Hiroshi Ishimoto, Hiroshi Mukae, Masataka Kuwana, S Kohno, Kazuhiko Takehara, Shinichi Sato, Katsumi Eguchi,

Immunodeficiency and Autoimmune Disorders

Objective: To determine the association of distinct clinical subsets with myositis‐specific autoantibodies (MSAs) towards anti‐155/140‐kDa polypeptides [anti‐155/140 antibodies (Abs)], anti‐140‐kDa polypeptides (anti‐140 Abs), and anti‐aminoacyl tRNA synthetases (ARS Abs) in Japanese patients with dermatomyositis (DM).Methods: We compared the clinical features and short‐term prognoses of 30 DM patients whose serological status included these MSAs. The MSAs were determined by immunoprecipitation.Results: Anti‐155/140 Abs (n = 5), anti‐140 Abs (n = 8), and anti‐ARS Abs (n = 7) did not overlap each other. All of the anti‐155/140 Ab‐positive patients (n = 5) were complicated by malignancies, as were all of the anti‐140 Ab‐positive patients (n = 8), who showed rapidly progressive interstitial lung disease (ILD). The survival rate at 6 months from the diagnosis of DM was significantly lower in the anti‐140 Ab‐positive patients than in the other patients.Conclusion: This is the first study to report, in a single cohort of DM patients, that distinct clinical subsets are distributed in an anti‐155/140 Ab‐positive group, an anti‐140 Ab‐positive group, or an anti‐ARS Ab‐positive group. Our data also confirm previous evidence that anti‐155/140 Abs are involved in malignancies and that anti‐140 Abs are involved in rapidly progressive ILD.