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MODIFICATION BY PROPRANOLOL OF CARDIOVASCULAR EFFECTS OF INDUCED HYPOGLYCÆMIA

1975; Elsevier BV; Volume: 305; Issue: 7918 Linguagem: Inglês

10.1016/s0140-6736(75)92195-9

1474-547X

R H Lloyd‐Mostyn, S. Oram,

Diet and metabolism studies

The cardiovascular effects of hypo-glycæmia, with and without beta-blockade, were compared in fourteen healthy men. Eight received insulin alone, and eight, including two of the original insulin-only group, were given propranolol and insulin. In the insulin-group the period of hypoglycæmia was associated with an increase in heart-rate and a fall in diastolic blood-pressure. In the propranolol-insulin group there was a significant fall in heart-rate in most subjects and an increase in diastolic pressure. Typical S-T/T changes occurred in the insulin-group but in none of the propranolol-insulin group. Hypertension in diabetics prone to hypoglycæmic attacks should not be treated with beta-blockers because these drugs may cause a sharp rise in blood-pressure in such patients.