Synthesis of tert -Butyl 6-Oxo-2-azaspiro[3.3]heptane-2-carboxylate
2009; American Chemical Society; Volume: 11; Issue: 16 Linguagem: Inglês
10.1021/ol901325s
ISSN1523-7060
AutoresMarvin J. Meyers, Inouk Muizebelt, Jim van Wiltenburg, David Brown, Atli Thorarensen,
Tópico(s)Synthesis of β-Lactam Compounds
ResumoTwo efficient and scaleable synthetic routes to previously unknown bifunctional tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate are described. This compound and related intermediates described herein are useful for further selective derivation on the azetidine and cyclobutane rings providing a convenient entry point to novel compounds accessing chemical space complementary to piperidine ring systems.
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