Galectin-9 expands unique macrophages exhibiting plasmacytoid dendritic cell-like phenotypes that activate NK cells in tumor-bearing mice
2008; Elsevier BV; Volume: 130; Issue: 3 Linguagem: Inglês
10.1016/j.clim.2008.09.014
ISSN1521-7035
AutoresAtsuya Nobumoto, Souichi Oomizu, Tomohiro Arikawa, Shigeki Katoh, Keiko Nagahara, Minoru Miyake, Nozomu Nishi, Keisuke Takeshita, Toshiro Niki, Akira Yamauchi, Mitsuomi Hirashima,
Tópico(s)Aluminum Alloys Composites Properties
ResumoGalectin-9 (Gal-9) inhibits the metastasis of tumor cells by blocking their adhesion to endothelium and the extracellular matrix. In this study, we addressed the involvement of Gal-9 in anti-tumor activity. Gal-9 significantly prolonged the survival of B16F10 melanoma-bearing mice. Gal-9 increased the numbers of NK cells, CD8 T cells and macrophages in tumor-bearing mice. Gal-9-mediated anti-tumor activity was not induced in NK cell-, macrophage- and CD8 T cell-depleted mice. NK cells from Gal-9-treated mice, compared to PBS-treated mice, exhibited significantly higher cytolytic activity. Co-culture of naïve NK cells with macrophages from Gal-9-treated mice resulted in enhanced NK activity, although Gal-9 itself did not enhance the NK activity. We also found that Ly-6C+CD11b+F4/80+ macrophages with plasmacytoid cell (pDC)-like phenotypes (PDCA-1 and B220) were responsible for the enhanced NK activity. These results provide evidence that Gal-9 promotes NK cell-mediated anti-tumor activity by expanding unique macrophages with a pDC-like phenotype.
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