Portal de Periódicos da CAPES

CRF mRNA in Normal and Stress Conditions

1993; Wiley; Volume: 697; Issue: 1 Linguagem: Inglês

10.1111/j.1749-6632.1993.tb49920.x

1749-6632

Stafford L. Lightman, Michael S. Harbuz, RICHARD A. KNIGHT, Hardial S. Chowdrey,

Childhood Cancer Survivors' Quality of Life

Annals of the New York Academy of SciencesVolume 697, Issue 1 p. 28-39 CRF mRNA in Normal and Stress Conditions STAFFORD L. LIGHTMAN, STAFFORD L. LIGHTMAN Neuroendocrinology Unit Charing Cross and Westminster Medical School Charing Cross Hospital Fulham Palace Road London W6 8RF, United Kingdom Present address: Department of Medicine, University of Bristol, Bristol Royal Infirmary, Marlborough Street, Bristol BS2 8HW, U. K.Search for more papers by this authorMICHAEL S. HARBUZ, MICHAEL S. HARBUZ Neuroendocrinology Unit Charing Cross and Westminster Medical School Charing Cross Hospital Fulham Palace Road London W6 8RF, United Kingdom Present address: Department of Medicine, University of Bristol, Bristol Royal Infirmary, Marlborough Street, Bristol BS2 8HW, U. K.Search for more papers by this authorRICHARD A. KNIGHT, RICHARD A. KNIGHT Department of Cystic Fibrosis National Heart and Lung Institute Brompton Hospital Manresa Road London SW3 6LR, United KingdomSearch for more papers by this authorHARDIAL S. CHOWDREY, HARDIAL S. CHOWDREY Neuroendocrinology Unit Charing Cross and Westminster Medical School Charing Cross Hospital Fulham Palace Road London W6 8RF, United Kingdom Present address: Department of Medicine, University of Bristol, Bristol Royal Infirmary, Marlborough Street, Bristol BS2 8HW, U. K.Search for more papers by this author STAFFORD L. LIGHTMAN, STAFFORD L. LIGHTMAN Neuroendocrinology Unit Charing Cross and Westminster Medical School Charing Cross Hospital Fulham Palace Road London W6 8RF, United Kingdom Present address: Department of Medicine, University of Bristol, Bristol Royal Infirmary, Marlborough Street, Bristol BS2 8HW, U. K.Search for more papers by this authorMICHAEL S. HARBUZ, MICHAEL S. HARBUZ Neuroendocrinology Unit Charing Cross and Westminster Medical School Charing Cross Hospital Fulham Palace Road London W6 8RF, United Kingdom Present address: Department of Medicine, University of Bristol, Bristol Royal Infirmary, Marlborough Street, Bristol BS2 8HW, U. K.Search for more papers by this authorRICHARD A. KNIGHT, RICHARD A. KNIGHT Department of Cystic Fibrosis National Heart and Lung Institute Brompton Hospital Manresa Road London SW3 6LR, United KingdomSearch for more papers by this authorHARDIAL S. CHOWDREY, HARDIAL S. CHOWDREY Neuroendocrinology Unit Charing Cross and Westminster Medical School Charing Cross Hospital Fulham Palace Road London W6 8RF, United Kingdom Present address: Department of Medicine, University of Bristol, Bristol Royal Infirmary, Marlborough Street, Bristol BS2 8HW, U. K.Search for more papers by this author First published: October 1993 https://doi.org/10.1111/j.1749-6632.1993.tb49920.xCitations: 14 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Dallman, M. F., S. F. Akana, N. Levin, et al. 1989. Corticosterone (B) replacement in adrenalectomized rats: Insight into the regulation of ACTH secretion. In The Control of the Hypothalamo-Pituitary-Adrenocortical Axis. F. C. Rose, Ed. International Universities Press. Madison , CT . 2 Waits, A. G. & L. W. Swanson. 1989. Diurnal variations in the content of preprocorticotropin-releasing hormone messenger ribonucleic acids in the hypothalamic paraventricular nucleus of rats of both sexes as measured by in situ hybridization. Endocrinology 125: 1734– 1738. 3 Jingami, H., S. Matsukura, S. Numa & H. Imura. 1985. Effects of adrenalectomy and dexamethasone administration on the level of prepro-corticotropin-releasing factor messenger ribonucleic acid (mRNA) in the hypothalamus and adrenocorticotropin/b lipotropin precursor mRNA in the pituitary in rats. Endocrinology 117: 1314– 1320. 4 Swanson, L. W. & D. M. Simmons. 1989. Differential steroid hormone and neural influences on peptide mRNA levels in CRH cells of the paraventricular nucleus: A hybridization histochemical study in the rat. 285: 413– 435. 5 Lightman, S. L., M. S. Harbuz & W. S. I. Young. 1992. Regulation of hypothalamic CRF mRNA. In Stress, Neuroendocrine and Molecular Approaches. R. Kvetnansky, R. McCarty & J. Axelrod, Eds. Gordon and Breach, New York , NY . 6 Dallman, M. F., N. Levin, C. S. Cascio, S. F. Akana, L. Jacobsen & R. W. Kuhn. 1989. Pharmacological evidence that the inhibition of diurnal adrenocorticotropin secretion by corticosteroids is mediated via type I corticosterone preferring receptors. Endocrinology 124: 2844– 2850. 7 Herman, J. P., S. J. Wiegand & S. J. Watson. 1990. Regulation of basal corticotropinreleasing hormone and arginine vasopressin messenger ribonucleic acid expression in the paraventricular nucleus: Effects of selective hypothalamic deafferentations. Endocrinology 127: 2408– 2417. 8 Herman, J. P., M. K. H. Shafer, E. A. Young, et al. 1989. Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis. J. Neurosci. 9: 3072– 3082. 9 Sapolsky, R. M., M. P. Armanine, S. W. Sutton & P. M. Plotsky. 1989. Elevation of hypophysial portal concentrations of adrenocorticotropin secretagogues after fornix transection. Endocrinology 125: 2881– 2887. 10 Imaki, T., T. Shibasaki, M. Hotta & H. Demara. 1992. Early induction of c-fos precedes increased expression of corticotrophin-releasing factor messenger ribonucleic acid in the paraventricular nucleus after immobilisation stress. Endocrinology 131: 240– 246. 11 Lightman, S. L. & W. S. Young III. 1988. Corticotrophin-releasing factor, vasopressin and proopiomelanocortin mRNA responses to stress and opiates in the rat. J. Physiol. 403: 511– 523. 12 Harbuz, M. S. & S. L. Lightman. 1989. Responses of hypothalamic and pituitary mRNA to physical and psychological stress in the rat. J. Endocrinol. 122: 705– 711. 13 Harbuz, M. S., J. A. Russell, B. E. H. Sumner, M. Kawata & S. L. Lightman. 1991. Rapid changes in the content of proenkephalin A and corticotrophin releasing hormone mRNAs in the paraventricular nucleus during morphine withdrawal in urethane-anaesthetized rats. Mol. Brain Res. 9: 285– 291. 14 Hokfelt, T., J. Fahrenkrug, K. Tatemoto, V. Mutt, S. Werner, A. L. Hulting, L. Terenius & K. J. Chang. 1983. The PHI (PHI-27)/corticotropin-releasing factor/ enkephalin immunoreactive hypothalamic neuron: Possible morphological basis for integrated control of prolactin, corticotropin, and growth hormone secretion. Proc. Natl. Acad. Sci. USA 80: 895– 898. 15 Hisano, S., Y. Tsuruo, S. Katoh, S. Daikoku, N. Yanaiharan & T. Shibasaki. 1987. Intragranular colocalization of arginine vasopressin and methionine-enkephalin-octapeptide in CRF-axons in the median eminence. Cell Tissue Res. 249: 497– 507. 16 Lightman, S. L. & W. S. Young III. 1989. Influence of steroids on the hypothalamic corticotropin-releasing factor and preproenkephalin mRNA responses to stress. Proc. Natl. Acad. Sci. USA 86: 4306– 4310. 17 Harbuz, M. S., S. A. Nicholson, B. Gillham & S. L. Lightman. 1990. Stress responsiveness of hypothalamic corticotrophin-releasing factor and pituitary proopiomelanocortin mRNAs following high dose glucocorticoid treatment and withdrawal in the rat. J. Endocrinol. 127: 407– 415. 18 Akana, S. F., M. F. Dallman, M. J. Bradbury, K. A. Scribner, A. M. Strack & C. D. Walker. 1992. Feedback and facilitation in the adrenocortical system: Unmasking facilitation by partial inhibition of the glucocorticoid response to prior stress. Endocrinology 131: 57– 68. 19 Lightman, S. L. & M. S. Harbuz. 1992. Expression of corticotropin-releasing factor mRNA in response to stress. In CIBA Foundation Symposium: 173– 187. Wiley. Chichester . 20 Khansari, D. N., A. J. Murgo & R. E. Faith. 1990. Effects of stress on the immune system. Immunol. Today 11: 170– 175. 21 Dunn, A. J. 1990. Interleukin 1 as a stimulator of hormone secretion. Prog. Neuro Endocrin Immunol. 3: 26– 29. 22 Rothwell, N. J. 1991. Functions and mechanisms of interleukin 1 in the brain. Trends Pharmacol. Sci. 12: 430– 436. 23 Harbuz, M. S. & S. L. Lightman. 1992. Stress and the hypothalamo-pituitary-adrenal axis: Acute, chronic and immunological activation. J. Endocrinol. 134: 327– 339. 24 Tsagarakis, S., G. Gillies, L. H. Rees, M. Besser & A. Grossman. 1989. Interleukin-1 directly stimulates the release of corticotrophin releasing factor from rat hypothalamus. Neuroendocrinology 49: 98– 101. 25 Hu, S. B., L. A. Tanahill & S. L. Lightman. 1992. Interleukin-1β (IL-1β) induces corticotropin releasing factor-41 release from cultured hypothalamic cells through protein kinase C and cAMP dependent protein kinase pathways. J. Neuroimmunol. 40: 49– 56. 26 Besedovsky, H., A. Del Rey, E. Sorkin & C. A. Dinarello. 1986. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science 233: 652– 654. 27 Sapolsky, R., C. Rivier, G. Yamamoto, P. Plotsky & W. Vale. 1987. Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science 238: 522– 524. 28 Harbuz, M. S., A. Stephanou, N. Sarlis & S. L. Lightman. 1992. The effects of recombinant interleukin (IL)-1α, IL-1β or IL-6 on hypothalamo-pituitary-adrenal axis activation. J. Endocrinol. 133: 349– 355. 29 Ovadia, H., O. Abramsky, V. Barak, N. Conforti, D. Saphier & J. Wiedenfeld. 1989. Effect of interleukin-1 on adrenocortical activity in intact and hypothalamic deafferen-tated male rats. Exp. Brain Res. 76: 246– 249. 30 Berkenbosch, F., J. Van Oers, A. Del Rey, F. Tilders & H. Besedovsky. 1987. Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1. Science 238: 524– 526. 31 Berkenbosch, F., D. E. C. De Goeij, A. Del Rey & H. O. Besedovsky. 1989. Neuroendocrine, sympathetic and metabolic responses induced by interleukin-1. Neuroendocrinology 50: 570– 576. 32 Suda, T., F. Tozawa, T. Ushiyama, T. Sumitomo, M. Yamada & H. Demura. 1990. Interleukin-1 stimulates corticotropin releasing factor gene expression in the rat hypothalamus. Endocrinology 126: 1223– 1229. 33 Chover-Gonzalez, A. J., M. S. Harbuz & S. L. Lightman. Effect of adrenalectomy and stress on interleukin-1β mediated activation of hypothalamic corticotropin releasing factor mRNA. J. Neuroimmunol. In press. 34 Weidenfeld, J., O. Abramsky & H. Ovadia. 1989. Effect of interleukin-1 on ACTH and corticosterone secretion in dexamethasone and adrenalectomized pretreated male rats. Neuroendocrinology 50: 650– 654. 35 Mason, D. 1991. Genetic variation in the stress response: Susceptibility to experimental allergic encephalomyelitis and implications for human inflammatory disease. Immunol. Today 12: 57– 60. 36 Harbuz, M. S., A. Stephanou, R. A. Knight, A. J. Chover-Gonzalez & L. L. S. Action of interleukin-2 and interleukin-4 on CRF mRNA in the hypothalamus and POMC mRNA in the anterior pituitary. Brain Behav. Immun. In press. 37 Pearson, C. M. 1956. Development of arthritis, periarthritis and periostitis in rats given adjuvant. Proc. Soc. Exp. Biol. Med. 91: 95– 103. 38 Chang, Y.-H., C. M. Pearson & C. Abe. 1980. Adjuvant polyarthritis. IV. Induction by a synthetic adjuvant: Immunologic, histopathologic, and other studies. Arthritis Rheum. 23: 62– 71. 39 Sarlis, N. J., A. Stephanou, H. S. Chowdrey, R. A. Knight & S. L. Lightman. 1992. Pituitary-adrenal axis and anterior pituitary prolactin and growth hormone mRNA responses of adjuvant-arthritic rats to cyclosporine A are dependent upon its time of administration. Prog. Neuro Endocrin Immunol. 5: 141– 150. 40 Harbuz, M. S., R. G. Rees, D. Eckland, D. S. Jessop, D. Brewerton & S. L. Lightman. 1992. Paradoxical responses of hypothalamic corticotropin releasing factor (CRF) messenger ribonucleic acid (mRNA) and CRF-41 peptide and adenohypophysial proopiomelanocortin mRNA during chronic inflammatory stress. Endocrinology 130: 1394– 1399. 41 Harbuz, M. S., R. G. Rees & S. L. Lightman. Hypothalamo-pituitary responses to acute stress and changes in circulating glucocorticoids during chronic adjuvant-induced arthritis in the rat. Am. J. Physiol. In press. 42 Sternberg, E. M., W. S. I. Young, R. Bernardini et al. 1989. A central nervous system defect in biosynthesis of corticotropin-releasing hormone is associated with susceptibility to streptococcal cell wall-induced arthritis in Lewis rats. Proc. Natl. Acad. Sci. USA 86: 4771– 4775. 43 Pearson, C. M. & F. D. Wood. 1963. Mycobacteria wax D subfractions in induction of adjuvant induced arthritis. Int. Arch. Allergy 35: 456– 464. 44 Berry, H., D. A. Willoughby & J. P. Giroud. 1973. Evidence for an endogenous antigen in the adjuvant arthritic rat. J. Pathol. 111: 229– 238. 45 Trentham, D. E., W. J. McCune, P. Susman & J. R. David. 1980. Autoimmunity to collagen in adjuvant arthritis of rats. J. Clin. Invest. 66: 1109– 1117. 46 Van Eden, W., J. Holoschitz, Z. Nevo, A. Frenkel, A. Klajman & I. R. Cohen. 1985. Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans. Proc. Natl. Acad. Sci. USA 82: 5117– 5120. 47 Holoschitz, J., A. Matitiau & I. R. Cohen. 1984. Arthritis induced in rats by cloned T lymphocytes responsive to bacteria but not to collagen type II. J. Clin. Invest. 73: 211– 215. 48 Shinmei, M., K. Masuda, T. Kikushi & Y. Shinomura. 1989. Interleukin 1, tumour necrosis factor and interleukin 6 as mediators of cartilage destruction. Semin. Arthritis Rheum. 18 (Suppl. 1): 27– 31. 49 Leisten, J. C., W. A. Gaarde & W. Scholz. 1990. Interleukin 6 serum levels correlate with footpad swelling in adjuvant-induced arthritic Lewis rats treated with cyclosporin A or indomethacin. Clin. Immunol. Immunopathol. 56: 108– 114. 50 Stephanou, A., N. J. Sarlis, R. A. Knight, H. S. Chowdrey & S. L. Lightman. 1992. Response of pituitary and spleen pro-opiomelanocortin mRNA, and spleen and thymus interleukin-1β mRNA to adjuvant arthritis in the rat. J. Neuroimmunol. 37: 59– 63. 51 Koenig, J. J., W. Snow, B. D. Clark, et al. 1990. Intrinsic pituitary interleukin-1β is induced by bacterial lipopolysaccharide. Endocrinology 126: 3053– 3058. 52 Carmeliet, P., H. Vankelekom, J. Van Damme, A. Billiau & C. Denef. 1991. Release of interleukin-6 from anterior pituitary cell aggregates: Developmental pattern and modulation by glucocorticoids and forskolin. Neuroendocrinology 53: 29– 34. 53 Stephanou, A., N. J. Sarlis, R. A. Knight, S. L. Lightman & H. S. Chowdrey. Effects of cyclosporine A on the hypothalamic-pituitary-adrenal axis and anterior pituitary interleukin-6 mRNA expression during chronic inflammatory stress in the rat. J. Neuroimmunol. In press. 54 Zhang, Y., J.-X. Lin & J. Vilcek. 1988. Synthesis of interleukin 6 (interferon β2-B cell stimulating factor) in human fibroblasts is supported by an increase in intracellular cyclic AMP. J. Biol. Chem. 263: 6177– 6180. 55 Walther, Z., L. T. May & P. B. Seghal. 1988. Transcriptional regulation of the interferon β2/B cell differentiation factor BSF2/hepatocyte stimulating factor gene in human fibroblasts by other cytokines. J. Immunol. 140: 974– 978. 56 Naitoh, Y., J. Fukata, T. Tominaga et al. 1988. Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious, freely moving rats. Biochem. Biophys. Res. Commun. 155: 1459– 1463. 57 Uehara, A., P. E. Gottschall, R. P. Dahl & A. Arimura. 1987. Interleukin-1 stimulates ACTH release by an indirect action which requires endogenous corticotropin-releasing factor. Endocrinology 121: 1580– 1582. 58 Hirano, T., K. Yamada & K. Oka. 1988. Effects of cyclosporine on adrenocortical stress response of Wistar rats. Res. Commun. Chem. Pathol. Pharmacol. 60: 3– 5. 59 Bunjes, D., C. Hardt, M. Rollinghoff & H. Wagner. 1981. Cyclosporin A mediates immunosuppression of primary cytotoxic T cell response by impairing the release of interleukin 1 and interleukin 2. Eur. J. Immunol. 11: 657– 661. 60 Andrus, L. & K. J. Lafferty. 1982. Inhibition of T-cell activity by cyclosporin A. Scand. J. Immunol. 15: 449– 458. 61 Prince, H. E. & J. K. John. 1986. Cyclosporin inhibits the expression of receptors for interleukin 2 and transferrin on mitogen-activated human T lymphocytes. Immunol. Invest. 15: 463– 465. 62 Knight, R. A., A. Stephanou, N. J. Sarlis, H. S. Chowdrey & S. L. Lightman. Direct stimulation of the pituitary by transfer of activated leucocytes. Submitted. 63 Smith, E. M., S. F. Galin, R. D. LeBoeuf, D. H. Coppenhaver, D. V. Harbour & J. E. Blalock. 1990. Nucleotide and amino acid sequence of lymphocyte derived corticotropin: Endotoxin induction of a truncated peptide. Proc. Natl. Acad. Sci. USA 87: 1057– 1060. 64 Stephanou, A., D. S. Jessop, R. A. Knight & S. L. Lightman. 1990. Corticotrophin-releasing factor-like immunoreactivity and mRNA in human leukocytes. Brain Behav. Immun. 4: 67– 72. 65 Stephanou, A., R. A. Knight & S. L. Lightman. 1991. Production of a growth hormone-releasing hormone-like peptide and its mRNA by human lymphocytes. Neuroendocrinology 53: 628– 633. Citing Literature Volume697, Issue1Corticotropin‐Releasing Factor and Cytokines: Role in the Stress Response–Proceedings of the Hans Selye Symposium on Neuroendocrinology and StressOctober 1993Pages 28-39 ReferencesRelatedInformation