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Chromogenic and Fluorogenic Sensing of Biological Thiols in Aqueous Solutions Using BODIPY-Based Reagents

2012; American Chemical Society; Volume: 15; Issue: 1 Linguagem: Inglês

10.1021/ol303306s

1523-7060

Murat Işık, Tuğba Özdemir, Ilke Simsek Turan, Safacan Kölemen, Engin U. Akkaya,

Nanoplatforms for cancer theranostics

Judicious design of BODIPY dyes carrying nitroethenyl substituents in conjugation with the BODIPY core yields dyes that respond to biological thiols by both absorbance and emission changes. Incorporation of solubilizing ethyleneglycol units ensures water solubility. The result is bright signaling of biologically relevant thiols in the longer wavelength region of the visible spectrum and in aqueous solutions.