Produção Nacional
Oxidação Eletroquímica de Anlodipino e Hidroclorotiazida Sobre o Eletrodo de Diamante Dopado com Boro: Potencialidade de Determinação Simultânea em Urina
2015; FUNDAÇÃO UNIVERSIDADE FEDERAL DE MATO GROSSO DO SUL; Volume: 7; Issue: 1 Linguagem: Inglês
10.17807/orbital.v7i1.673
ISSN1984-6428
AutoresGuilherme Roberto Mansano, Elen Romão Sartori,
Tópico(s)Electrochemical sensors and biosensors
ResumoThe present study was undertaken to evaluate the use of boron-doped diamond electrode in the simultaneous voltammetric determination of antihypertensives amlodipine and hydrochlorothiazide in urine sample. Two very well-resolved and reproducible oxidation peaks of amlodipine and hydrochlorothiazide, with separation of 0.360 V, were obtained in Britton-Robinson buffer (pH 5.0). Under the optimum analytical experimental conditions, the square-wave voltammetric method exhibited linear responses for simultaneous determination of amlodipine and hydrochlorothiazide in the concentration range 1.0 × 10−7 – 2.1 × 10−6 mol L−1 and 2.0 × 10−6 – 2.2 × 10−5 mol L−1, with detection limits of 5.6 × 10−8 mol L−1 and 1.6 × 10−7 mol L−1, respectively. The proposed method was applied in the simultaneous determination of amlodipine and hydrochlorothiazide in urine sample. DOI: http://dx.doi.org/10.17807/orbital.v7i1.673
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