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Artigo Revisado por pares
BIBTEX RIS

Bioactive Isomalabaricane Triterpenes from the Marine Sponge Rhabdastrella g lobostellata

2002; American Chemical Society; Volume: 65; Issue: 2 Linguagem: Inglês

10.1021/np0104020

ISSN

1520-6025

Autores

Deniz Taşdemir, Gina C. Mangalindan, Gisela P. Concepción, Sheryl M. Verbitski, Sridhar K. Rabindran, Miriam Miranda, Michael Greenstein, John N. A. Hooper, Mary Kay Harper, Chris M. Ireland,

Tópico(s)

Synthesis and Biological Activity

Resumo

Two new isomalabaricane triterpenes, stellettin H (1) and stellettin I (2), have been isolated from the marine sponge Rhabdastrella globostellata, collected from the Philippines. Stellettins A-D (3-6), (-)-stellettin E (7), and rhabdastrellic acid-A (8) were also isolated and characterized. Stellettin B (4) and (-)-stellettin E (7) showed selective cytotoxicity toward p21(WAF1/Cip1)-deficient human colon tumor (HCT-116) cells with IC(50) values of 0.043 and 0.039 microM, respectively.

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