Portal de Periódicos da CAPES

LH AND FSH TO GnRH ASSESED BY TWO HIGHLY SENSITIVE ASSAYS IN NORMAL PUBERTY, DELAYED PUBERTY (DP) AND HYPOCONADOTROPIC HYPOGONADISM (HH)

1993; Springer Nature; Volume: 33; Linguagem: Inglês

10.1203/00006450-199305001-00511

1530-0447

Mirta Stivel, G García Arias, S B Campeni, Cecilia Zylbersztein, H.E. Scaglia, A Oneto, C. Aranda,

Testicular diseases and treatments

The Basal (B) on GnRH (P) stimulated levels of LH and FSH were measured by ultrasen sitive (0.4 and 0.3 mUI/ml) IRMA (CIS International) assay in 54 normal children: pre pubertal (PP n=24 (M 11, F 13); Early Pubertal (EP) n=17 (M9, F8); Advanced Pubertal (AP) n=13 (M8, F5). 10 patients (M8, F2) with DP {Tanner I, test vol.< 3, CA: n ± SD: 13.84 ± 1.14 y, BA: 11.94 ± 0.47 y) and 9 patients with HH (Tanner I, test vol 2 mUI/ml values. B FSH levels was detectable in all the groups and was significantly (p< 0.03) greater in F than in M in PP. Upon GnRH test, the distinction between the groups was better. P LH x ± DS PP: 2.93 ± 0.94 vs EP: 10.34 ± 4.93 (P< 0.0001) vs AP: 21.8 ± 8.98 mUI/ml (p<0.0001). No statically difference was found between IRMA or IFMA. All of the PP, F and M, had a ratio P LH to P FSH which was less than 1 and increased significantly with pubertal onset. In DP, before the appearance of pubertal signs, at BA 11.94 ± 0.47 y, the LH response to the Gn RH was 10.40 ± 4.60 vs 2.61 ± 2.14 mUI/ml (p <0.0001) in HH. LH responses did not overlap in either group. We conclude, that the test of Gn RH using gonadotropin ultrasensitive assay is useful in identifying the onset of puberty, and in the discrimination of DP from HH.