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Membrane Localization of Protein-Tyrosine Phosphatase 1B is Essential for its Activation of Sterol Regulatory Element-Binding Protein-1 Gene Expression and Consequent Hypertriglyceridaemia

2009; Oxford University Press; Volume: 146; Issue: 4 Linguagem: Inglês

10.1093/jb/mvp104

1756-2651

Satoshi Ugi, Kun Shi, Yusuke Nishio, S. Shimizu, Bin Guo, O Sekine, Kazuhiro Ikeda, Katsuya Egawa, Takeshi Yoshizaki, Yoshio Nagai, Daisuke Koya, Tatsuyuki Takada, Ryuzo Torii, Hiroshi Kimurâ, Akihiko Kashiwagi, Hiroshi Maegawa,

Protein Kinase Regulation and GTPase Signaling

Journal Article Membrane Localization of Protein-Tyrosine Phosphatase 1B is Essential for its Activation of Sterol Regulatory Element-Binding Protein-1 Gene Expression and Consequent Hypertriglyceridaemia Get access Satoshi Ugi, Satoshi Ugi * 1Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan; 2Department of Gynecology and Obstetrics, Harbin Medical University, Harbin 150086, China; 3Research Center for Animal Life Science; and 4Department of Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan *To whom correspondence should be addressed. Tel: +81-77-548-2223, Fax: +81-77-543-3858, E-mail: sugi@belle.shiga-med.ac.jp Search for other works by this author on: Oxford Academic PubMed Google Scholar Kun Shi, Kun Shi 1Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan; 2Department of Gynecology and Obstetrics, Harbin Medical University, Harbin 150086, China; 3Research Center for Animal Life Science; and 4Department of Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Yoshihiko Nishio, Yoshihiko Nishio 1Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan; 2Department of Gynecology and Obstetrics, Harbin Medical University, Harbin 150086, China; 3Research Center for Animal Life Science; and 4Department of Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Shinya Shimizu, Shinya Shimizu 1Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan; 2Department of Gynecology and Obstetrics, Harbin Medical University, Harbin 150086, China; 3Research Center for Animal Life Science; and 4Department of Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Baoliang Guo, Baoliang Guo 1Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan; 2Department of Gynecology and Obstetrics, Harbin Medical University, Harbin 150086, China; 3Research Center for Animal Life Science; and 4Department of Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Osamu Sekine, Osamu Sekine 1Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan; 2Department of Gynecology and Obstetrics, Harbin Medical University, Harbin 150086, China; 3Research Center for Animal Life Science; and 4Department of Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Kazuhiro Ikeda, Kazuhiro Ikeda 1Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan; 2Department of Gynecology and Obstetrics, Harbin Medical University, Harbin 150086, China; 3Research Center for Animal Life Science; and 4Department of Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Katsuya Egawa, Katsuya Egawa 1Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan; 2Department of Gynecology and Obstetrics, Harbin Medical University, Harbin 150086, China; 3Research Center for Animal Life Science; and 4Department of Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Takeshi Yoshizaki, Takeshi Yoshizaki 1Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan; 2Department of Gynecology and Obstetrics, Harbin Medical University, Harbin 150086, China; 3Research Center for Animal Life Science; and 4Department of Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Yoshio Nagai, Yoshio Nagai 1Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan; 2Department of Gynecology and Obstetrics, Harbin Medical University, Harbin 150086, China; 3Research Center for Animal Life Science; and 4Department of Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar ... Show more Daisuke Koya, Daisuke Koya 1Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan; 2Department of Gynecology and Obstetrics, Harbin Medical University, Harbin 150086, China; 3Research Center for Animal Life Science; and 4Department of Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Tatsuyuki Takada, Tatsuyuki Takada 1Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan; 2Department of Gynecology and Obstetrics, Harbin Medical University, Harbin 150086, China; 3Research Center for Animal Life Science; and 4Department of Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Ryozo Torii, Ryozo Torii 1Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan; 2Department of Gynecology and Obstetrics, Harbin Medical University, Harbin 150086, China; 3Research Center for Animal Life Science; and 4Department of Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Hiroshi Kimura, Hiroshi Kimura 1Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan; 2Department of Gynecology and Obstetrics, Harbin Medical University, Harbin 150086, China; 3Research Center for Animal Life Science; and 4Department of Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Atsunori Kashiwagi, Atsunori Kashiwagi 1Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan; 2Department of Gynecology and Obstetrics, Harbin Medical University, Harbin 150086, China; 3Research Center for Animal Life Science; and 4Department of Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Hiroshi Maegawa Hiroshi Maegawa 1Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan; 2Department of Gynecology and Obstetrics, Harbin Medical University, Harbin 150086, China; 3Research Center for Animal Life Science; and 4Department of Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 146, Issue 4, October 2009, Pages 541–547, https://doi.org/10.1093/jb/mvp104 Published: 15 July 2009 Article history Received: 30 March 2009 Accepted: 18 June 2009 Published: 15 July 2009