Immunological Studies of Human Gliomas
1965; American Association of Neurological Surgeons; Volume: 23; Issue: 4 Linguagem: Inglês
10.3171/jns.1965.23.4.0363
ISSN1933-0693
Autores Tópico(s)Medical Imaging Techniques and Applications
ResumoI N THE search for new and more rewarding approaches to the diagnosis and t r ea tmen t of nlal ignant gliomas, a s tudy of the antigenic potent ia l of this ra ther unique type of t umor was init iated. The glioblastoma mult i forme is characterized by its infiltrative and locally invasive behavior, the rar i ty of true metastasis , the proliferation of supportive vascular s t roma, and a tendency of the tumor to recur despite surgical resection, irradiation therapy , and chemotherapy. Previous experiments wi th the use of regional carotid chemotherapeut ic perfusion and infusion have demons t ra ted the lack of specificity of ant i -cancer agents and their toxicity to normal brain tissue. 10,1s,19 Del ivery of radioact ivi ty or an ant i-cancer agent to a glioma by use of specific an t ibody carriers would offer ano ther approach to the diagnosis and t r ea tmen t of these tumors. Specific localization of radioiodine emit t ing energetic gamma ray would sharpen the tumor profile obtained by external scanning procedures. 12 Specific localization of radioiodine emit t ing beta rays might be expected to concentrate therapeut ic amoun t s of radioac t iv i ty within the t u m o r wi th nfinimal radiat ion damage to the ad jacent normal brain t issue? These considerations led to an investigat ion of the antigenic potent ia l of human gliomas, based upon an exper imenta l model sys tem with ra t hepa toma, s Thus , the in
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