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Anatomically dependent anticonvulsant properties of temporally-coded electrical stimulation

2012; Elsevier BV; Volume: 23; Issue: 3 Linguagem: Inglês

10.1016/j.yebeh.2012.01.004

1525-5069

Daniel de Castro Medeiros, Vinícius Rosa Cota, Maura Regina Silva da Páscoa Vilela, Flávio Afonso Gonçalves Mourão, André Ricardo Massensini, Márcio Flávio Dutra Moraes,

Neurological disorders and treatments

In the PTZ animal model of epilepsy, electrical stimulation applied to the amygdaloid complex may result in either pro-convulsive or anticonvulsant effect, depending on the temporal pattern used (i.e. periodic-PS and non-periodic-NPS electrical stimulation). Our hypothesis is that the anatomical target is a determinant factor for the differential effect of temporally-coded patterns on seizure outcome. The threshold dose of PTZ to elicit forelimb clonus and generalized tonic–clonic seizure behavior was measured. The effect of amygdaloid complex PS on forelimb clonus threshold showed a pro-convulsive effect while NPS was anticonvulsant. NPS also significantly increased generalized tonic–clonic threshold; while PS, although at lower threshold levels, did not present statistical significance. Thalamus stimulation did not affect forelimb clonus threshold and showed similar anticonvulsant profiles for both PS and NPS on generalized tonic–clonic threshold. In summary, the anatomical target is a determinant factor on whether temporally-coded ES differentially modulates seizure outcome.