Interaction of ultrasound with neoplastic tissue Local effect on subcutaneously implanted furth-columbia rat wilms' tumor
1975; Elsevier BV; Volume: 6; Issue: 5 Linguagem: Inglês
10.1016/0090-4295(75)90520-8
ISSN1527-9995
AutoresFrank W. Longo, Walter E. Longo, Philip Tomashefsky, John K. Lattimer, Bernard D. Rivin, Myron Tannenbaum,
Tópico(s)Ultrasound and Hyperthermia Applications
ResumoUltrasonic irradiation was employed by direct administration to the skin overlying subcutaneously implanted Furth-Columbia rat Wilms' tumors. Treated tumors were flattened and excavated and demonstrated no stigmata of hemorrhage or infection. There was a marked decrease in growth rate of the tumors with an increase in survival time of the host. Histologic assessment with the light microscope exhibited a sharp line of demarcation between the necrosed sonicated portion of tumor and the viable intact nonsonicated area of tumor. A blackened area of skin, which was not histologically similar to a burn, was interposed between the site of application of the ultrasound and the necrosed tumor.
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