Polymeric formulations for drug release prepared by hot melt extrusion: application and characterization
2015; Elsevier BV; Volume: 20; Issue: 7 Linguagem: Inglês
10.1016/j.drudis.2015.01.012
ISSN1878-5832
AutoresMilica Stanković, Henderik W. Frijlink, Wouter L.J. Hinrichs,
Tópico(s)Advanced Drug Delivery Systems
ResumoOver the past few decades hot melt extrusion (HME) has emerged as a powerful processing technology for the production of pharmaceutical solid dosage forms in which an active pharmaceutical ingredient (API) is dispersed into polymer matrices. It has been shown that formulations using HME can provide time-controlled, sustained and targeted drug delivery, and improved bioavailability of poorly soluble drugs. In this review, the basic principles of the HME process are described together with an overview of some of the most common biodegradable and nonbiodegradable polymers used for the preparation of different formulations using this method. Further, the applications of HME in drug delivery and analytical techniques employed to characterize HME products are addressed.
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